This verse can be troubling. If Jesus is God's Son, then why would God forsake him at the moment of his greatest need?

Some have said that this is the point at which your sin and mine were laid upon him, and God, being holy, could no longer commune with Jesus at this point.

An additional thought is that Jesus, in his agony, was reciting the first line of Psalm 22. Between gasps for air, he may have only been able to utter the first line, knowing that those witnesses who were familiar with the Psalms would understand the rest.

The crucifixion is the darkest day in human history, no doubt, but even amid the horror of the death of God's own sinless Son--even when he felt abandoned by His Heavenly Father--he knew that victory was coming. Psalm 22 is not only about feeling forsaken by God, but it is also prophetic. It is about salvation, deliverance, obedience, and the future certainty that God will be glorified. Jesus knew that his present suffering, however brutal, was winning an eternal victory for God the Father, for Himself, for the Holy Spirit, and for us who by grace will never be God-forsaken again.

Psalm 22:1 and Mark 15:34